[Antimicrobial and antitrichomonal activity of 5-nitroimidazole derivatives in an in vitro experiment].

Abstract	The comparative study on the antimicrobial activity of metronidazole and its complex with cobalt sulfate showed that the complex formation increased 2-4 times the metronidazole activity against elective anaerobes. The study of the drug action on Trichomonas spp. revealed that as a result of the complexing with cobalt sulfate the metronidazole efficacy against the Trichomonas strains isolated from the discharge of a female patient with metronidazole resistant trichomoniasis increased, the activating effect of the complex on the host cells being suggested.
Authors	A S Seleznev, G A Dmitriev, E E Bragina, N I Kaletina, L A Pavlova, Ia V Murza, R A Abdumalikov
Journal	Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic] (Antibiot Khimioter) Vol. 40 Issue 2 Pg. 14-8 (Feb 1995) ISSN: 0235-2990 [Print] Russia (Federation)
Vernacular Title	Antimikrobnaia i protivotrikhomonadnaia aktivnost' proizvodnykh 5-nitroimidazola v éksperimente in vitro.
PMID	7605136 (Publication Type: Comparative Study, English Abstract, Journal Article)
Chemical References	Metronidazole Cobalt cobalt sulfate
Topics	Cobalt (chemistry) Female Humans Metronidazole (chemistry, pharmacology) Microbial Sensitivity Tests

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