Cardiac beta-receptors in experimental Chagas' disease.

Abstract

Experimental Chagas' disease (45 to 90 days post-infection) showed serious cardiac alterations in the contractility and in the pharmacological response to beta adrenergic receptors in normal and T. cruzi infected mice (post-acute phase). Chagasic infection did not change the beta receptors density (78.591 +/- 3.125 fmol/mg protein and 73.647 +/- 2.194 fmol/mg protein for controls) but their affinity was significantly diminished (Kd = 7.299 +/- 0.426 significantly diminished (Kd = 7.299 +/- 0.426 nM and Kd = 3.759 +/- 0.212 nM for the control) p < 0.001. This results demonstrate that the alterations in pharmacological response previously reported in chagasic myocardium are related to a significantly less beta cardiac receptor affinity. During this experimental period serious cardiac cell alterations take place and functional consequences will be detected in the chronic phase.

• Authors: J E Enders, P Paglini, A R Fernandez, F Marco, J A Palma
• Journal: Revista do Instituto de Medicina Tropical de Sao Paulo (Rev Inst Med Trop Sao Paulo) 1995 Jan-Feb Vol. 37 Issue 1 Pg. 59-62 ISSN: 0036-4665 [Print] Brazil
• PMID: 7569641 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Adrenergic beta-Antagonists
• Receptors, Adrenergic, beta
• Dihydroalprenolol

Topics

• Adrenergic beta-Antagonists (metabolism)
• Analysis of Variance
• Animals
• Chagas Disease (physiopathology)
• Dihydroalprenolol (metabolism)
• Heart Ventricles (physiopathology)
• Mice
• Myocardial Contraction (drug effects)
• Receptors, Adrenergic, beta (analysis, metabolism, physiology)