Abstract |
The circulatory responses to progressively increasing doses of angiotensin II were studied in the same group of chronically instrumented unanesthetized pregnant sheep during three consecutive periods: a) normotensive with intact kidneys; b) normotensive with unilateral nephrectomy; and c) one-kidney hypertension. The results show that 1) the pressor response to a given dose of angiotensin was significantly greater in the normotensive than in the hypertensive condition; 2) uterine blood flow decreased markedly with the development of hypertension; 3) uterine circulatory response to angiotensin depended on the dosage; the response was less the the hypertensive than in the normotensive condition; 4) renal blood flow decreased and renal vascular resistance increased during angiotensin infusion, but the response was less in the hypertensive than in the normotensive condition; the response of the renal circulation decreased with increasing doses of angiotensin. These observations suggest a generalized vascular refractoriness to exogenous angiotensin II in the pregnant ewe with experimental renal hypertension.
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Authors | S M Lieb, T Cabalum, M Zugaib, R Erkkola, K Tabsh, E Ushioda, B S Nuwayhid, C R Brinkman 3rd, N S Assali |
Journal | The American journal of physiology
(Am J Physiol)
Vol. 238
Issue 2
Pg. H209-13
(Feb 1980)
ISSN: 0002-9513 [Print] United States |
PMID | 7361915
(Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)
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Chemical References |
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Topics |
- Angiotensin II
(pharmacology)
- Animals
- Blood Pressure
(drug effects)
- Dose-Response Relationship, Drug
- Female
- Hypertension, Renal
(physiopathology)
- Kidney
(blood supply)
- Pregnancy
- Pregnancy Complications, Cardiovascular
(physiopathology)
- Pregnancy, Animal
- Regional Blood Flow
(drug effects)
- Sheep
(physiology)
- Uterus
(blood supply)
- Vascular Resistance
(drug effects)
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