The biological significance of estradiol receptor binding to DNA.

Abstract

MTW9-D, a rat mammary tumor derived from MTW9 by chronic administration of the dopamine antagonist drug R33,812 shows ovariectomy-induced regression (OIR). MTW9-MtT is also a variant of MTW9, grown by coimplantation of a mammosomatotropic tumor MtTW10, but it does not show OIR. However, when the mammosomatotropic tumor (MtT) is resected, the tumor regresses and shows rapid OIR; implantation of MtT into animals bearing MTW9-D prevents OIR following drug withdrawal. The estradiol receptor (ER) from MTW9-D cytosol binds to DNA-cellulose significantly more than that from MTW9-MtT. After MtT resection, the mammary tumor ER binds to DNA-cellulose, as well as ER from MTW9-D, whereas implantation of MtT into animals bearing MTW9-D decreases ER binding to DNA-cellulose. The significance of these findings in relation to possible clinical application is discussed.

• Authors: S Khan, M Feldman, V P Hollander
• Journal: Cancer research (Cancer Res) Vol. 40 Issue 4 Pg. 1050-3 (Apr 1980) ISSN: 0008-5472 [Print] United States
• PMID: 7357535 (Publication Type: Comparative Study, Journal Article, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Receptors, Estrogen
• Estradiol
• Prolactin
• DNA

Topics

• Animals
• Castration
• DNA (metabolism)
• Estradiol (metabolism)
• Female
• In Vitro Techniques
• Mammary Neoplasms, Experimental (metabolism, therapy)
• Neoplasms, Experimental (metabolism)
• Neoplasms, Hormone-Dependent (metabolism)
• Prolactin (metabolism, physiology)
• Rats
• Rats, Inbred WF
• Receptors, Estrogen (metabolism)