Isolation of geodiastatins 1 and 2 from the marine sponge Geodia mesotriaena.

Abstract

An aqueous extract of the Gulf of California Geodia mesotriaena von Lendenfeld (Porifera) has been found to contain two chromoprotein antineoplastic agents designated geodiastatins 1 and 2. The active brownish-black proteins from this siliceous sponge were found to contain major (greater than 1%) amounts of silicon and to inhibit growth of the murine P388 lymphocytic leukemia. A related protein (geodiatoxin 1) was found to be toxic at 6 mg/kg (LI100, mouse).

• Authors: G R Pettit, J A Rideout, J A Hasler
• Journal: Journal of natural products (J Nat Prod) 1981 Sep-Oct Vol. 44 Issue 5 Pg. 588-92 ISSN: 0163-3864 [Print] United States
• PMID: 7320740 (Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Antineoplastic Agents
• Luminescent Proteins
• geodiastatins

Topics

• Animals
• Antineoplastic Agents (isolation & purification)
• Lethal Dose 50
• Leukemia P388 (drug therapy)
• Luminescent Proteins (isolation & purification, pharmacology, toxicity)
• Mice
• Porifera (analysis)