[Effectiveness of amphoglucamine in experimental candidiasis in sex hormone administration].

Abstract

The efficacy of amphoglucamine was tested on male and female albino mice infected intravenously with Candida albicans and treated with testosterone and folliculin in doses of 1 mg and 10 units per mouse respectively. It was shown that 0.25 per cent of the experimental mice treated with testosterone alone survived, while the use of amphoglucamine alone in a dose of 1 mg/kg per os provided the survival of 0.5 per cent of the animals. With the use of the both drugs in combination almost all animals survived. Combined treatment with amphoglucamine and folliculin was not effective: isolation of Candida from all organs persisted, the spleen index changed insignificantly. Under the effect of testosterone the level of the spleen contamination was lower as compared to the control. The use of testosterone for a definite period of time promoted elimination of Candida from the internal organs. No significant difference in the titers of the complement-binding antibodies in the group of the mice treated with both the drugs was observed. It is suggested that the effect of the sex hormones on the fungus infection is associated with changing of the cell protective mechanisms.

• Authors: M A Mikhaĭlova, G A Ezhkov
• Journal: Antibiotiki (Antibiotiki) Vol. 26 Issue 6 Pg. 469-73 (Jun 1981) ISSN: 0003-5637 [Print] Russia (Federation)
• Vernacular Title: Effektivnost' amfogliukamina pri éksperimental'nom kandidoze na fone vvedeniia polovykh gormonov.
• PMID: 7271261 (Publication Type: Comparative Study, English Abstract, Journal Article)

Chemical References

• Antifungal Agents
• Estrone
• Testosterone
• amphoglucamine
• Amphotericin B

Topics

• Amphotericin B (analogs & derivatives, therapeutic use)
• Animals
• Antifungal Agents
• Candidiasis (drug therapy)
• Drug Evaluation, Preclinical
• Drug Therapy, Combination
• Estrone (therapeutic use)
• Female
• Male
• Mice
• Testosterone (therapeutic use)
• Time Factors