Abstract |
A 71-year-old previously hypercholesterolemic woman developed gradually severe hypocholesterolemia of 1.55 mmol/l. Simultaneously she developed progressive sideroblastic anemia, altered erythrocyte morphology and defective platelet function. Hypo-beta-lipoproteinemia was demonstrated with abnormal lipid composition of both very low density (VLDL), low density ( LDL) and high density lipoprotein (HDL) fractions. Other plasma lipids, as well as erythrocyte lipids, were normal. The fractional catabolic rate of homologous 125I-LDL was increased to 4-5-fold, while its rate of synthesis was normal. The patient's serum contained autoantibodies directed against LDL. It is concluded that her hypo-beta-lipoproteinemia was due to autoantibodies towards LDL causing an increased catabolism without any concomitant effect on the rate of LDL synthesis. It is suggested that acquired hypo-beta-lipoproteinemia can be subdivided into two types, one in which the primary defect is an increased catabolism due to immunoelimination, and another in which the primary defect is a decreased rate of LDL synthesis.
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Authors | K S Bjerve, S A Evensen, S Stray-Pedersen, S Skrede |
Journal | Acta medica Scandinavica
(Acta Med Scand)
Vol. 211
Issue 4
Pg. 313-8
( 1982)
ISSN: 0001-6101 [Print] Sweden |
PMID | 7102370
(Publication Type: Case Reports, Journal Article)
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Chemical References |
- Autoantibodies
- Lipoproteins, HDL
- Lipoproteins, LDL
- Lipoproteins, VLDL
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Topics |
- Aged
- Anemia, Sideroblastic
(etiology)
- Autoantibodies
(analysis)
- Female
- Humans
- Hypercholesterolemia
(complications)
- Hypobetalipoproteinemias
(etiology, immunology, metabolism)
- Hypolipoproteinemias
(etiology)
- Lipoproteins, HDL
(metabolism)
- Lipoproteins, LDL
(immunology, metabolism)
- Lipoproteins, VLDL
(metabolism)
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