Failure of systemically administered corticosteroids to suppress UVB-induced delayed erythema.

Abstract

The effects of systemic corticosteroids on ultraviolet-induced delayed erythema were observed in a double-blind controlled study. The backs of human volunteers were irradiated with ultraviolet B (UVB) sources, and subsequent response was observed while ingesting prednisone (80 mg by mouth for 3 days) of placebo. Prednisone given 24 hours before, immediately after, 24 hours or 48 hours after exposure did not increase the redness, edema, or tenderness of the exposed sites.

• Authors: J S Greenwald, J A Parrish, K F Jaenicke, R R Anderson
• Journal: Journal of the American Academy of Dermatology (J Am Acad Dermatol) Vol. 5 Issue 2 Pg. 197-202 (Aug 1981) ISSN: 0190-9622 [Print] United States
• PMID: 7021612 (Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)

Chemical References

• Prednisone

Topics

• Clinical Trials as Topic
• Double-Blind Method
• Erythema (drug therapy)
• Humans
• Prednisone (therapeutic use)
• Sunburn (drug therapy)
• Time Factors
• Ultraviolet Rays (adverse effects)