The anti-inflammatory action of nepitrin, a flavonoid.

Abstract

The anti-inflammatory efficacy of nepitrin (5,3',4'-trihydroxy-6-methoxy flavone), a flavonoid, was investigated in both acute and chronic models of inflammation in rats. Nepitrin was found to possess significant anti-inflammatory activity in the exudative and proliferative phases of inflammation. This action of nepitrin could be due to its anti-bradykinin and anti-angiotensin action. Nepitrin also possessed anti-pyretic and weak analgesic activity. The study reveals that nepitrin may be useful as an anti-inflammatory and anti-arthritic agent.

• Authors: O P Agarwal
• Journal: Agents and actions (Agents Actions) Vol. 12 Issue 3 Pg. 298-302 (Jul 1982) ISSN: 0065-4299 [Print] Switzerland
• PMID: 6982607 (Publication Type: Journal Article)

Chemical References

• Anti-Inflammatory Agents
• Anti-Inflammatory Agents, Non-Steroidal
• Flavonoids
• Luteolin
• nepitrin

Topics

• Animals
• Anti-Inflammatory Agents
• Anti-Inflammatory Agents, Non-Steroidal
• Arthritis (drug therapy)
• Arthritis, Experimental (drug therapy)
• Edema (drug therapy)
• Flavonoids (pharmacology)
• Luteolin
• Muscle Contraction (drug effects)
• Muscle, Smooth (drug effects)
• Rats