[Morphologic studies on the occurrence of HBs antigen in liver cirrhoses, epicirrhotic and pure cancers in a large autopsy sample].

Abstract

1063 hepatic cirrhoses, 138 epicirrhotic carcinomas, and 138 carcinomas without cirrhosis from the autopsy material of the Dresden region obtained from 1970 to 1979 were examined for the occurrence of HBsAg by means of reclassification and after-staining of the documented section material with orcein staining according to Shikata. The portion of the post-B-hepatic cirrhoses of the liver was 95 (8.9 per cent of the total material). In epicirrhotic carcinomas a HBsAg-containing cirrhotic portion was identified in 14 cases (10.1 per cent), whereas hepatic tissue of carcinomas without cirrhosis never showed HBsAg. A relation between the activity degree of the hepatic cirrhosis and the quantity and distribution of HBsAg could not be established. The found out numbers (about equally frequent occurrence of HBsAg in hepatic cirrhosis and epicirrhotic carcinomas, no identification in the hepatic tissue of carcinomas without cirrhosis) reveal that the thesis of a hepatocarcinogenic effect of the hepatitis B virus cannot be supported by the histologic identification of HBsAg in our investigational material. The possibility of confusion of ground-glass hepatocytes with liver oncocytes in the HE-stained section material of the autopsy material is pointed out.

• Authors: H Riedel, J Hensel, J Justus
• Journal: Deutsche Zeitschrift fur Verdauungs- und Stoffwechselkrankheiten (Dtsch Z Verdau Stoffwechselkr) Vol. 43 Issue 1 Pg. 9-16 ( 1983) ISSN: 0012-1053 [Print] Germany
• Vernacular Title: Morphologische Untersuchungen zum Vorkommen des HBs-Antigen in Leberzirrhosen, epizirrhotischen und reinen Karzinomen an einem umfangreichen Obduktionsgut.
• PMID: 6840031 (Publication Type: English Abstract, Journal Article)

Chemical References

• Hepatitis B Surface Antigens

Topics

• Aged
• Female
• Hepatitis B (immunology, pathology)
• Hepatitis B Surface Antigens (analysis)
• Humans
• Liver (pathology)
• Liver Cirrhosis (immunology, pathology)
• Liver Neoplasms (immunology, pathology)
• Male
• Necrosis