Treatment of corneal xerophthalmia with topical retinoic acid.

Abstract

Retinoic acid 0.1% in arachis oil was applied to one eye and arachis oil alone to the other eye, of each of 19 patients with equivalent degrees of corneal xerophthalmia in the fellow eyes. Even with concomitant systemic vitamin A therapy, topical retinoic acid was associated with more rapid healing of corneal lesions in a substantial proportion of cases. Application of retinoic acid three times a day produced no significant side effects; application five times a day, however, resulted in moderate to severe conjunctival injection and increased corneal vascularization and scarring.

• Authors: A Sommer
• Journal: American journal of ophthalmology (Am J Ophthalmol) Vol. 95 Issue 3 Pg. 349-52 (Mar 1983) ISSN: 0002-9394 [Print] United States
• PMID: 6829680 (Publication Type: Journal Article)

Chemical References

• Vitamin A
• Tretinoin

Topics

• Administration, Topical
• Corneal Diseases (drug therapy)
• Humans
• Tretinoin (administration & dosage)
• Vitamin A (therapeutic use)
• Xerophthalmia (drug therapy)