The oncostatic effect of methyl-CCNU on various experimental lymphoreticular neoplasms.

Abstract

Studies on the chemotherapeutic potential of methyl-CCNU on experimental leukemias were undertaken. A number of murine transplantable in vivo lines (chemical carcinogen-induced T and B leukemias; radiation- and viral-induced T leukemias of C57BL/6, C3H/eb and SJL/J origin; radiation-induced myeloid leukemias and spontaneous reticulum cell neoplasms of SJL/J mine) were used in these studies. The optimal dose of methyl-CCNU and optimal timing of administration were extensively investigated on two sample lines of T cell leukemias of C57BL/6 mice. Leukemic cell eradication could be achieved in almost all of the different leukemias treated, irrespective of whether induction was brought about by chemical or physical means or due to a viral leukemogenic agent. Studies undertaken to elucidate the effect of methyl-CCNU on the establishment of preleukemic cells following induction of leukemia by the radiation leukemia virus (RadLV) or by total body irradiation, indicated the oncostatic effect of methyl-CCNU on early preleukemic cells.

• Authors: A Peled, K Perk, N Haran-Ghera, M A Chirigos
• Journal: Leukemia research (Leuk Res) Vol. 6 Issue 1 Pg. 89-95 ( 1982) ISSN: 0145-2126 [Print] England
• PMID: 6803071 (Publication Type: Comparative Study, Journal Article, Research Support, U.S. Gov't, Non-P.H.S.)

Chemical References

• Nitrosourea Compounds
• Semustine
• 9,10-Dimethyl-1,2-benzanthracene

Topics

• 9,10-Dimethyl-1,2-benzanthracene
• Animals
• Blood Cell Count
• Body Weight
• Drug Administration Schedule
• Drug Evaluation, Preclinical
• Female
• Hematocrit
• Leukemia, Experimental (drug therapy, etiology)
• Leukemia, Radiation-Induced (drug therapy)
• Mice
• Mice, Inbred Strains
• Nitrosourea Compounds (therapeutic use)
• Precancerous Conditions (drug therapy, etiology)
• Retroviridae
• Semustine (therapeutic use)