Influence of thioctic acid (alpha-lipoic acid) on N-nitroso-diethylamine-induced carcinogenesis in male sprague-dawley rats.

Abstract

Male Sprague-Dawley rats received 10 mg/kg body weight of N-nitroso-diethylamine by gavage twice weekly for life (group 1). An additional daily application of thioctic acid (alpha-lipoic acid) in drinking water (45 mg/kg body weight/day) (group 2) and 180 mg/kg body weight/day (group 3) did not significantly influence tumor frequencies, induction times and histology of the induced liver and esophageal tumors. A postulated enhancing mechanism on tumor development due to thioctic acid treatment could not be demonstrated.

• Authors: M Habs, H Habs, D Schmähl
• Journal: Arzneimittel-Forschung (Arzneimittelforschung) Vol. 30 Issue 10 Pg. 1715-7 ( 1980) ISSN: 0004-4172 [Print] Germany
• PMID: 6776963 (Publication Type: Journal Article)

Chemical References

• Carcinogens
• Nitrosamines
• Diethylnitrosamine
• Thioctic Acid

Topics

• Animals
• Carcinogens
• Diethylnitrosamine (toxicity)
• Drug Interactions
• Male
• Nitrosamines (toxicity)
• Rats
• Thioctic Acid (pharmacology)