Induction of digestive-tract tumors in F344 rats by continuous oral administration of N-butyl-N-nitrosourea.

Abstract

Male and female F344/DuCrj rats were administered N-butyl-N-nitrosourea at a concentration of 400 ppm in their drinking water. By the 50th week of the experiment, the cumulative incidence of upper-digestive-tract tumors was as high as 35/39 (90%) and 34/39 (87%) in male and female rats, respectively. Among these, esophageal and forestomach tumors occurred most frequently. Except one female rat with fibroma, upper-digestive-tract neoplasms were of the epithelial type -- papilloma, squamous-cell carcinoma or adenocarcinoma. In female rats, vaginal tumors were induced in 16 (41%) animals. Ear-duct tumors and hematopoietic neoplasms were also induced in both sexes of rats, with incidence of less than 21%.

• Authors: M Takeuchi, T Ogiu, C Matsuoka, K Furuta, A Maekawa, M Nakadate, S Odashima
• Journal: Journal of cancer research and clinical oncology (J Cancer Res Clin Oncol) Vol. 107 Issue 1 Pg. 32-7 ( 1984) ISSN: 0171-5216 [Print] Germany
• PMID: 6699073 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Nitrosourea Compounds
• N-nitrosobutylurea

Topics

• Adenocarcinoma (chemically induced)
• Animals
• Carcinoma, Squamous Cell (chemically induced)
• Digestive System Neoplasms (chemically induced, pathology)
• Drinking
• Ear Neoplasms (chemically induced)
• Female
• Intestinal Neoplasms (chemically induced)
• Leukemia (chemically induced)
• Male
• Nitrosourea Compounds (administration & dosage)
• Papilloma (chemically induced)
• Rats
• Rats, Inbred F344
• Time Factors
• Vaginal Neoplasms (chemically induced)