Phototoxicity from furocoumarins (psoralens) of Heracleum laciniatum in a patient with vitiligo. Action spectrum studies on bergapten, pimpinellin, angelicin and sphondin.

Abstract

Investigations on light reactions in a patient with vitiligo are presented. The minimal erythema dose (MED) in the UVB area was approximately 1/3 of that in persons of skin type II. The application of furocoumarins (psoralens) increased light tolerance by 1 MED at 300-310 nm. Action spectrum studies with furocoumarins from Heracleum laciniatum showed the following order of potency: bergapten, pimpinellin, angelicin and sphondin. The efficacy was highest at 325-350 nm, with maxima at 330-335 nm. Pimpinellin was recently found to be phototoxic, but an action spectrum of sphondin is reported for the first time.

• Authors: G Kavli, K Midelfart, J Raa, G Volden
• Journal: Contact dermatitis (Contact Dermatitis) Vol. 9 Issue 5 Pg. 364-6 (Sep 1983) ISSN: 0105-1873 [Print] England
• PMID: 6627920 (Publication Type: Case Reports, Comparative Study, Journal Article)

Chemical References

• Anticonvulsants
• Furocoumarins
• Intercalating Agents
• Tranquilizing Agents
• sphondin
• 5-Methoxypsoralen
• angelicin
• pimpinellin
• Methoxsalen

Topics

• 5-Methoxypsoralen
• Adult
• Anticonvulsants (toxicity)
• Female
• Furocoumarins (toxicity)
• Humans
• Intercalating Agents (toxicity)
• Isomerism
• Methoxsalen (analogs & derivatives, toxicity)
• Photosensitivity Disorders (etiology)
• Plants, Toxic (analysis)
• Radiation Dosage
• Spectrophotometry, Ultraviolet (methods)
• Tranquilizing Agents (toxicity)
• Ultraviolet Rays (adverse effects)
• Vitiligo (complications)