Glycosylated hemoglobin as a screening test for carbohydrate intolerance in pregnancy.

Abstract

The usefulness of glycosylated hemoglobin as a prenatal screening test for carbohydrate intolerance was studied in 806 consecutive subjects by correlating glycosylated hemoglobin to 1-hour post-50 gm Glucola plasma glucose (1 degree G) levels, and 3-hour oral glucose tolerance tests (3 degrees GTT). Sixty-seven subjects whose 1 degree G greater than or equal to 150 mg/100 ml received a 3 degrees GTT; 12 were diagnostic of carbohydrate intolerance. Compared to carbohydrate-tolerant controls, carbohydrate-intolerant gravid patients had higher 1 degree G (p less than 0.001) and glycosylated hemoglobin (p less than 0.05) levels. Linear regression analysis of 1 degree G and glycosylated hemoglobin demonstrated r = 0.35 (p less than 0.0001). Compared to the glycosylated hemoglobin test, the 1 degree G screening test has greater specificity, sensitivity, and predictive value for a positive diagnosis. Consequently, the 1 degree G is a better routine screening test for carbohydrate intolerance than is glycosylated hemoglobin.

• Authors: L Cousins, B J Dattel, D R Hollingsworth, A Zettner
• Journal: American journal of obstetrics and gynecology (Am J Obstet Gynecol) Vol. 150 Issue 5 Pt 1 Pg. 455-60 (Nov 01 1984) ISSN: 0002-9378 [Print] United States
• PMID: 6496578 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Glycated Hemoglobin A

Topics

• Diabetes Mellitus (diagnosis)
• Evaluation Studies as Topic
• Female
• Glucose Tolerance Test
• Glycated Hemoglobin (analysis)
• Humans
• Pregnancy
• Pregnancy Complications (diagnosis)
• Regression Analysis