Interaction of cytotoxic antibiotic dactylarin with glycolytic thiol enzymes in Ehrlich ascites carcinoma cells.

Abstract

Cytotoxic effect of dactylarin on Ehrlich ascites carcinoma cells is caused by the inhibition of some SH-dependent glycolytic enzymes, especially of hexokinase (EC 2.7.1.1), glyceraldehyde-3-phosphate dehydrogenase (EC 1.2.1.12) and 6-phosphofructokinase (EC 2.7.1.11). Dactylarin interacts with thiols, which explains its inhibitory effectiveness on the above glycolytic enzymes.

• Authors: E Sturdík, L Drobnica
• Journal: The Journal of antibiotics (J Antibiot (Tokyo)) Vol. 34 Issue 6 Pg. 708-12 (Jun 1981) ISSN: 0021-8820 [Print] England
• PMID: 6456251 (Publication Type: Journal Article)

Chemical References

• Anti-Bacterial Agents
• Benzofurans
• Lactates
• Sulfhydryl Compounds
• dactylarin
• L-Lactate Dehydrogenase
• Glucosephosphate Dehydrogenase
• Glyceraldehyde-3-Phosphate Dehydrogenases
• Hexokinase
• Phosphofructokinase-1
• Glucose

Topics

• Animals
• Anti-Bacterial Agents (pharmacology)
• Benzofurans (pharmacology)
• Carcinoma, Ehrlich Tumor (metabolism)
• Cells, Cultured
• Glucose (metabolism)
• Glucosephosphate Dehydrogenase (metabolism)
• Glyceraldehyde-3-Phosphate Dehydrogenases (metabolism)
• Hexokinase (metabolism)
• L-Lactate Dehydrogenase (metabolism)
• Lactates (biosynthesis)
• Mice
• Phosphofructokinase-1 (metabolism)
• Sulfhydryl Compounds (metabolism)