[Clinical results of cefoperazone in pediatric infections (author's transl)].

Abstract

In order to evaluate effectiveness of cefoperazone (CPZ) in the treatment of bacterial infections of children, the clinical studies were carried out. CPZ was administered by one-shot injection to 28 patients at daily dose of 50 approximately 160 (average 89.7) mg/kg in 3 approximately 4 divided dose for 2 approximately 10 (average 5.6) days. The overall efficacy rate in 28 cases was 92.9%, i.e., excellent in 16 (57.1%), good in 10 (35.7%), fair in 1 (3.6%) and poor in 1 case (3.6%). Temporary rise of GOT and GPT or only GOT was observed in each 1 case out of 28 cases (7.1%), but any other abnormality was not observed throughout this series. Based on the above results, CPZ was thus considered to be a useful antibiotic in treatment of pediatric infections caused by Gram-positive cocci and Gram-negative rods.

• Authors: M Miyao, Y Kuroda, H Tanaka, M Mizui, Y Uyama, Y Yuasa
• Journal: The Japanese journal of antibiotics (Jpn J Antibiot) Vol. 33 Issue 9 Pg. 931-4 (Sep 1980) ISSN: 0368-2781 [Print] Japan
• PMID: 6452542 (Publication Type: English Abstract, Journal Article)

Chemical References

• Cephalosporins
• Cefoperazone

Topics

• Age Factors
• Bacterial Infections (drug therapy, microbiology)
• Cefoperazone
• Cephalosporins (pharmacology, therapeutic use)
• Child
• Child, Preschool
• Drug Evaluation
• Drug Resistance, Microbial
• Female
• Humans
• Infant
• Infant, Newborn
• Male