Cefoperazone (Cefoperazone Sodium)

Semisynthetic broad-spectrum cephalosporin with a tetrazolyl moiety that is resistant to beta-lactamase. It may be used to treat Pseudomonas infections.

Also Known As:

Cefoperazone Sodium; Cefobid; Cefoperazon; Cefoperazone Sodium Salt; Céfobis; T-1551; T1551; Salt, Cefoperazone Sodium; Sodium Salt, Cefoperazone; Sodium, Cefoperazone; T 1551; 5-Thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid, 7-(((((4-ethyl-2,3-dioxo-1-piperazinyl)carbonyl)amino)(4-hydroxyphenyl)acetyl)amino)-3-(((1-methyl-1H-tetrazol-5-yl)thio)methyl)-8-oxo-, (6R-(6alpha,7beta(R*)))-

Networked: 673 relevant articles (98 outcomes, 118 trials/studies)

Relationship Network

Drug Context: Research Results

Experts

1.	Lai, Chih-Cheng: 5 articles (04/2022 - 02/2020)
2.	Li, Ying: 4 articles (01/2020 - 01/2018)
3.	Young, Vincent B: 4 articles (01/2020 - 01/2012)
4.	Tang, Hung-Jen: 3 articles (04/2022 - 01/2019)
5.	Schwarz, Stefan: 3 articles (02/2017 - 05/2012)
6.	Gao, Chunlu: 2 articles (08/2022 - 07/2016)
7.	Chen, Yuancheng: 2 articles (05/2022 - 01/2016)
8.	Wang, Minggui: 2 articles (05/2022 - 11/2018)
9.	Zhang, Jing: 2 articles (05/2022 - 01/2016)
10.	Chao, Chien-Ming: 2 articles (04/2022 - 10/2021)

Related Diseases

1.	Infections 01/01/1984 - "Cefoperazone appears to be extremely useful in the treatment of various infections in hospitalized patients." 01/01/1981 - "In conclusion, cefoperazone was considered to be effective in treating biliary tract infections because of its broad antibacterial spectrum and high penetration into bile." 03/01/1991 - "Patients with infections due to gram-negative organisms responded well to all three agents, whereas patients with gram-positive infections responded more favorably to cefoperazone. " 11/01/1992 - "The therapeutic efficacy of liposomal cefoperazone against Pseudomonas aeruginosa was investigated in a granulocytopenic mouse model of acute lung infection. " 01/01/1981 - "Twice daily dosing with cefoperazone appears to be effective against numerous Gram-positive and Gram-negative bacteria in a variety of clinical infections."
2.	Bacterial Infections (Bacterial Infection) 01/01/1986 - "These favourable properties, together with its good antibacterial activity, suggest that cefoperazone will be effective in treating bacterial infections in human beings." 01/01/1981 - "The high cefoperazone concentrations found in serum and different tissues lead us to expect successful therapy when cefoperazone is used to treat bacterial infections with sensitive pathogens in the urogenital tract." 03/01/1983 - "Cefoperazone sodium in the treatment of serious bacterial infections in 2,100 adults and children: multicentered trials in Europe, Latin America, and Australasia." 01/01/1981 - "Clinical studies with cefoperazone in the treatment of bacterial infections in surgical practice." 09/01/1980 - "In order to evaluate effectiveness of cefoperazone (CPZ) in the treatment of bacterial infections of children, the clinical studies were carried out. "
3.	Respiratory Tract Infections (Respiratory Tract Infection) 01/01/1983 - "Cefoperazone was found to be effective in the treatment of lower respiratory tract infections." 07/01/1989 - "[CEFOBID in the treatment of respiratory tract infection (preliminary report)]." 05/01/1989 - "Clinical effectiveness of cefoperazone (CPZ) was studied for 46 elderly patients with respiratory infections. " 05/01/1989 - "[Clinical effectiveness of cefoperazone for respiratory infections of elderly patients, focusing on its safety on renal function]." 10/01/1986 - "Clinical evaluation and kinetics in serum of cefoperazone (CPZ) in patients with lower respiratory tract infections have been conducted as a multicenter trial participated by 20 institutions in Kyushu area during a period of 8 months from October 1984 to May 1985. "
4.	Pneumonia (Pneumonitis) 01/01/1981 - "All of these patients were infected by organisms sensitive to cefoperazone by disc testing but in 5 of those who relapsed the cefoperazone MIC was in fact greater than or equal to 50 microgram/ml. Ten of 11 cases with radiologically confirmed pneumonia were cured with cefoperazone. " 01/01/1981 - "The efficacy of cefoperazone in patients with pneumonia was: good in 11 (73%), fair in 3, and poor in 1. In pyelonephritis, 12 (80%) responded well and in the other 3 response was fair. " 01/01/1998 - "Eighteen (95%) of 19 patients with pneumonia and 8 (89%) of 9 patients with pyogenic meningitis responded to cefoperazone. " 08/01/1990 - "In 8 cases recurrent urinary tract infections were diagnosed, septicaemia in 3 cases, pneumonia in 2. Cefoperazone 2-4 g daily was a very effective and well tolerated drug. " 01/01/1981 - "15 cases of pneumonia and 15 cases of pyelonephritis were included in a clinical trial of parenteral cefoperazone. "
5.	Neoplasms (Cancer) 03/01/1983 - "Cefoperazone was used for the treatment of 105 febrile episodes in 103 patients with cancer. " 01/01/2020 - "This study provides a systematic virtual screening approach for discovering HDAC6 active inhibitors, and by which the specific effect of cefoperazone sodium against HDAC6 was found, suggesting its potential application on cancer therapy." 08/01/1992 - "[Experience with using cefoperazone in cancer patients after bone marrow transplantation]." 07/25/1988 - "Previous studies have shown that cefoperazone given in frequent, large doses is effective in the treatment of infection in patients with cancer. " 03/01/1983 - "This study indicates that cefoperazone has low toxicity and is effective for the treatment of infections in patients with cancer."

Related Drugs and Biologics

1.	Sulbactam
2.	Anti-Bacterial Agents (Antibiotics)
3.	Ceftriaxone (Ceftriaxon)
4.	Cefotaxime (Kendrick)
5.	Ceftazidime (Fortum)
6.	Cephalosporins (Cephalosporin Antibiotics)
7.	Moxalactam (Latamoxef)
8.	Piperacillin
9.	beta-Lactamases (beta-Lactamase)
10.	Tazobactam Drug Combination Piperacillin (Zosyn)

Related Therapies and Procedures

1.	Therapeutics
2.	Intravenous Administration
3.	Tracheostomy
4.	Intravenous Injections
5.	Intramuscular Injections