Abstract |
Two formulations of avermectin B1a, C-076 and MK-933, were examined for anthelmintic activity in two trials, each using 20 calves with experimentally produced nematode infections. In one trial, C-076 was given orally, and in the other trial, MK-933 was given by injection at dosages of 50, 100, and 200 micrograms/kg of body weight. Treated calves were held for 7 to 8 days and then, together with nontreated controls, were euthanatized and were examined for nematodes in their gastrointestinal tracts and lungs. Efficacy of C-076 approached 100% for Dictyocaulus viviparus, Ostertagia ostertagi, Trichostrongylus axei, T colubriformis, and Oesophagostomum radiatum at 50 micrograms/kg. A dosage level of 100 micrograms/kg was required to achieve 97% efficacy against Cooperia punctata. Efficacy of MK-933 at 50 micrograms/kg was variable, but at 100 micrograms/kg, it approached 100% for D viviparus, O ostertagi, Haemonchus placei, T axei, and T longispicularis. Activity against C oncophora was less, reaching 80% efficacy at 200 micrograms/kg.
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Authors | R B Wescott, C J Farrell, A M Gallina, W J Foreyt |
Journal | American journal of veterinary research
(Am J Vet Res)
Vol. 41
Issue 8
Pg. 1326-8
(Aug 1980)
ISSN: 0002-9645 [Print] United States |
PMID | 6449894
(Publication Type: Comparative Study, Journal Article)
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Chemical References |
- Anthelmintics
- Lactones
- avermectin B(1)a
- Ivermectin
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Topics |
- Animals
- Anthelmintics
(therapeutic use)
- Cattle
- Cattle Diseases
(drug therapy)
- Dictyocaulus Infections
(drug therapy)
- Ivermectin
(analogs & derivatives)
- Lactones
(therapeutic use)
- Nematode Infections
(drug therapy, veterinary)
- Oesophagostomiasis
(drug therapy, veterinary)
- Trichostrongylosis
(drug therapy, veterinary)
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