Topically applied erythromycin in inflammatory acne vulgaris.

Abstract

We evaluated the effectiveness of 2% erythromycin and its alcohol/propylene glycol vehicle in the treatment of three hundred forty-eight patients with inflammatory acne vulgaris. A significantly greater reduction was noted in the papulopustule count for the erythromycin-treated group compared to the vehicle-treated group. Additionally, clinical improvement, as measured by physician global ratings, was significantly greater in the erythromycin-treated group. A lower adverse reaction rate observed in the erythromycin-treated patients may result from previously demonstrated anti-inflammatory properties of this antibiotic.

• Authors: J E Bernstein, A R Shalita
• Journal: Journal of the American Academy of Dermatology (J Am Acad Dermatol) Vol. 2 Issue 4 Pg. 318-21 (Apr 1980) ISSN: 0190-9622 [Print] United States
• PMID: 6444958 (Publication Type: Clinical Trial, Controlled Clinical Trial, Journal Article)

Chemical References

• Erythromycin

Topics

• Acne Vulgaris (drug therapy)
• Administration, Topical
• Adolescent
• Adult
• Erythromycin (administration & dosage, adverse effects, therapeutic use)
• Female
• Humans
• Male