The biological activity of 4-chloromethylbiphenyl, benzyl chloride and 4-hydroxymethylbiphenyl in 4 short-term tests for carcinogenicity. A report of an individual study in the UKEMS genotoxicity trial 1981.

Abstract

4-Chloromethylbiphenyl (4CMB), benzyl chloride (BC) and 4-hydroxymethyl-biphenyl (4HMB) were tested for biological activity in the following assays: (i) the Salmonella/microsome assay; (ii) a bacterial 'fluctuation' assays; (iii) a DNA repair assay in Hela cells, and (iv) a mouse lymphoma mutation assay. 4CMB was active in assays (i), (ii) and (iii) but not in (iv); BC was active in assays (i), (ii), (iii) but not in (iv) while 4HMB was inactive in all assays. Where biological activity was seen this did not require addition of a liver S9 preparation. 4CMB was more active than BC in all the test systems in which a positive response was obtained. The implication of these results for a test battery approach to in vitro testing is discussed.

• Authors: S C Booth, A J Mould, A Shaw, R C Garner
• Journal: Mutation research (Mutat Res) Vol. 119 Issue 2 Pg. 121-33 (Feb 1983) ISSN: 0027-5107 [Print] Netherlands
• PMID: 6338366 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Benzyl Compounds
• Biphenyl Compounds
• Carcinogens
• 4-hydroxymethylbiphenyl
• 4-chloromethylbiphenyl
• benzyl chloride

Topics

• Animals
• Benzyl Compounds (pharmacology)
• Biotransformation
• Biphenyl Compounds (pharmacology)
• Carcinogens
• DNA Repair
• HeLa Cells
• Mice
• Mutagenicity Tests
• Mutation (drug effects)
• Rats
• Salmonella typhimurium (drug effects)