Cutaneous cytodestructive potency of lignans. II. A comparative evaluation of macroscopic-toxic influence on rabbit skin subsequent to repeated 10-day applications.

Abstract	Four lignans: podophyllotoxin (A), 4'-demethyl-podophyllotoxin (B), alpha-peltatin (C), and beta-peltatin (D) are the podophyllin ingredients producing lesional necrosis after application on condylomata acuminata. This study evaluates comparatively their destructive potency on rabbit skin after 10-day repeated applications. Any visible changes or increase on skinfold thickness induced by each of the drugs tested as 0.01, 0.05, 0.1, and 0.5% ethanolic preparations were followed. These variables demonstrated a close covariation; the analyses revealed a significant difference with respect to influence on measurements according to the following ranking order: A greater than C greater than D = B.
Authors	G von Krogh, H I Maibach
Journal	Dermatologica (Dermatologica) Vol. 167 Issue 2 Pg. 70-7 ( 1983) ISSN: 0011-9075 [Print] Switzerland
PMID	6313441 (Publication Type: Comparative Study, Journal Article)
Chemical References	Antineoplastic Agents, Phytogenic Lignans Plant Extracts Podophyllotoxin
Topics	Administration, Topical Animals Antineoplastic Agents, Phytogenic (administration & dosage, metabolism) Condylomata Acuminata (drug therapy, pathology) Humans Kinetics Lignans Necrosis Plant Extracts (administration & dosage, metabolism) Podophyllotoxin (administration & dosage, metabolism) Rabbits Skin (pathology) Skinfold Thickness

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.

Realize the full power of the drug-disease research graph!