[Effect of epidermal chalones on the development and growth of cheek pouch tumors in the hamster].

Abstract

To the cheek pouch mucosa of 118 male Syrian golden hamsters 0.5% acetone solution of 7,12-dimethylbenz (a) anthracene was applied 3 times a week during 2 months. Two months after beginning of the experiments all the hamsters developed tumors. Since that time a mixture of epidermal G1 and G2 chalones was applied to the cheek pouch mucosa of the experimental animals 5 times a week. The control hamsters received saline alone. As compared to the control, the experimental hamsters demonstrated an increase in the life-span, tumor growth retardation and regression of part of the tumors. The data obtained attest to the anti-neoplastic action of chalones.

• Authors: P G Godorozha, M A Zabezhinskiĭ, V B Okulov, Iu G Puchkov, G B Pliss
• Journal: Biulleten' eksperimental'noi biologii i meditsiny (Biull Eksp Biol Med) Vol. 94 Issue 11 Pg. 68-9 (Nov 1982) ISSN: 0365-9615 [Print] Russia (Federation)
• Vernacular Title: Deĭstvie épidermal'nykh keĭlonov na razvitie i rost opukholeĭ zashchechnogo meshka khomiachka.
• PMID: 6217849 (Publication Type: English Abstract, Journal Article)

Chemical References

• Growth Inhibitors
• 9,10-Dimethyl-1,2-benzanthracene

Topics

• 9,10-Dimethyl-1,2-benzanthracene
• Animals
• Carcinoma, Squamous Cell (chemically induced, pathology)
• Cheek
• Cricetinae
• Growth Inhibitors (pharmacology)
• Male
• Mouth Neoplasms (chemically induced, pathology)
• Neoplasms, Experimental (chemically induced, pathology)