Chalones

Peptides that inhibit mitosis (ANTIMITOTICS). During the 1960's the term referred to crude extracts that inhibited cell proliferation; the activity was later attributed to PYROGLUTAMATE type oligopeptides.

Networked: 45 relevant articles (1 outcomes, 3 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Elgjo, Kjell: 1 article (08/2013)
2.	Reichelt, Karl L: 1 article (08/2013)
3.	Bakthavatsalam, Deenadayalan: 1 article (07/2009)
4.	Choe, Jonathan M: 1 article (07/2009)
5.	Gomer, Richard H: 1 article (07/2009)
6.	Hanson, Nana E: 1 article (07/2009)

Related Diseases

1.	Polycythemia Vera 07/01/1981 - "[Experimental data on the possible use of chalones in treating erythremia]." 01/01/1985 - "Based on an analysis of the data pertaining to changes in the level of erythropoietin, chalones and stress hormones in the blood of patients with polycythemia vera after bloodletings and cytapheresis it is concluded that chalones participate in the development of a remission owing to the inhibition of the clone of mutant cells. "
2.	Neoplasms (Cancer) 02/14/1978 - "The aim of this study was to investigate whether chalones were involved in the regulation of in vitro growth of JB-1 tumor cells. " 01/01/1983 - "Cancer as a problem in intercellular communication: regulation by growth-inhibiting factors (Chalones)." 11/01/1982 - "[Effect of epidermal chalones on the development and growth of cheek pouch tumors in the hamster]." 09/01/1981 - "The results indicate the possibility of using chalones as inhibitors of tumor growth." 09/01/1981 - "[Effect of epidermal chalones on the proliferation and differentiation of tumors of the lower lip in mice]."
3.	Psoriasis (Pustulosis Palmaris et Plantaris) 02/01/1982 - "This method can be applied equally well to fetal, newborn, or adult keratinocytes and should be useful in a variety of studies including isolation of subpopulations of pathological cell types, work on chalones and hyperplastic diseases such as psoriasis, and in vitro transformation studies." 06/01/1984 - "The serum of patients with progressive psoriasis lessens the inhibitory activity of epidermal chalones if it is added to the cultural medium before chalones. " 06/01/1984 - "[Biological activity of epidermal chalones in the presence of blood serum from patients with psoriasis]." 03/01/1981 - "[Modifying effect of the blood serum of patients with psoriasis on the inhibitory activity of epidermal chalones]."
4.	Neoplasm Metastasis (Metastasis) 01/01/1984 - "An assumption is advanced that the primary tumour synthesizing chalones and secreting them into blood can regulate not only its own growth but also the growth of remoted metastases." 07/27/2009 - "Several studies have shown that organ size, and the proliferation of tumor metastases, may be regulated by negative feedback loops in which autocrine secreted factors called chalones inhibit proliferation. " 01/07/1983 - "Unrestrained tumor growth is attributed to the inability of endogenous body chalones to suppress the non-body gene groups coding for neoplastic mitosis, while invasion and metastasis result from failure of the non-body genes which code for implantation and mitosis to switch off at the proper time. "
5.	Ascites 08/01/2013 - "It would entail that normal cell regulation such as growth, mitosis inhibition and differentiation would probably be lost, especially as we recover the missing compounds (chalones) from the incubation fluid or ascites. " 01/01/1978 - "Comparing the action of cell proliferation inhibitors (chalones) from Ehrlich ascites tumour and spleen lymphocytes it was shown that inhibition of 3H-thymidine incorporation occurs only with those cells corresponding to the origin of the inhibitor. " 11/07/1975 - "Employment of synchronized cells and flow microfluorometry in investigations on the JB-1 ascites tumour chalones." 11/01/1975 - "An examination of biochemical parameters that might regulate the growth fraction of Ehrlich ascites tumors by causing accumulation of cells in G1-G0 shows that (a) the tumor progresses from an aerobic to an anerobic state as it approaches the plateau phase of growth, as indicated by lactate dehydrogenase content, but cellular adenosine triphosphate content remains constant; (b) tumor-specific growth inhibitors (chalones) are not detectable in cell-free ascites fluid from plateau-phase tumors; (c) electrophoretically identifiable soluble proteins isolated from tumor cells that have been exposed to labeled amino acids in vivo are qualitatively identical during early and late tumor growth; and (d) ornithine decarboxylase activity increases in a bimodal fashion in the first 10 hr after transplantation of 10(7) cells and then declines rapidly during the first few days of growth. "

Related Drugs and Biologics

1.	Hormones (Hormone)
2.	Erythropoietin
3.	Proteins (Proteins, Gene)
4.	Intercellular Signaling Peptides and Proteins (Growth Factors)
5.	Nucleic Acids
6.	DNA (Deoxyribonucleic Acid)
7.	Cytostatic Agents
8.	Acetic Acid (Vinegar)
9.	Phorbol Esters
10.	Ornithine Decarboxylase (Decarboxylase, Ornithine)

Related Therapies and Procedures

1.	Transplantation
2.	Therapeutics
3.	Radiotherapy
4.	Injections