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Intracerebroventricular injection of cerebrospinal fluid (CSF) from a patient with congenital indifference to pain induces analgesia in rats.

Abstract
CSF from a patient with congenital indifference to pain was found to produce analgesia in the rat following intracerebroventricular injections. The analgesic effect was attenuated by pretreatment with naloxone suggesting the involvement of hyperactive endogenous opiate mechanisms in this patient.
AuthorsA Fabbri, F Fraioli, G Cruccu, M Manfredi, C B Pert, A Pert
JournalExperientia (Experientia) Vol. 40 Issue 12 Pg. 1365-6 (Dec 15 1984) ISSN: 0014-4754 [Print] Switzerland
PMID6210210 (Publication Type: Journal Article)
Chemical References
  • Receptors, Opioid
  • Naloxone
Topics
  • Adult
  • Analgesia
  • Animals
  • Cerebrospinal Fluid (physiology)
  • Humans
  • Injections, Intraventricular
  • Male
  • Naloxone (pharmacology)
  • Pain Insensitivity, Congenital (cerebrospinal fluid)
  • Rats
  • Rats, Inbred Strains
  • Receptors, Opioid (physiology)

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