The Brompton mixture: effects on pain in cancer patients.

Abstract

Terminally ill cancer patients were given the Brompton mixture and a phenothiazine in an attempt to control their pain. The mixture was administered to patients in three hospital environments: a palliative care unit (PCU), general wards and private rooms. Pain was measured in 92 patients with the McGill-Melzack Pain Questionnaire. The Brompton mixture controlled pain in 90% of patients in the PCU and in 75% to 80% of patients in the wards or private rooms. The differences in pain scores between the PCU patients and the other groups were significant. The mixture produced substantial decreases in the three major dimensions of pain: sensory, affective and evaluative. Comparison of these results with data obtained in an outpatient pain clinic showed that the Brompton mixture was strikingly more effective than the traditional methods of managing cancer pain.

• Authors: R Melzack, J G Ofiesh, B M Mount
• Journal: Canadian Medical Association journal (Can Med Assoc J) Vol. 115 Issue 2 Pg. 125-9 (Jul 17 1976) ISSN: 0008-4409 [Print] Canada
• PMID: 58710 (Publication Type: Journal Article)

Chemical References

• Antipsychotic Agents
• Drug Combinations
• Phenothiazines
• Solutions
• Ethanol
• Morphine
• Cocaine

Topics

• Affect
• Antipsychotic Agents (therapeutic use)
• Attitude
• Cocaine (administration & dosage, therapeutic use)
• Drug Combinations
• Ethanol (administration & dosage, therapeutic use)
• Evaluation Studies as Topic
• Female
• Hospital Units
• Humans
• Male
• Morphine (administration & dosage, therapeutic use)
• Neoplasms
• Pain, Intractable (drug therapy)
• Palliative Care
• Phenothiazines
• Sensation
• Solutions
• Surveys and Questionnaires