The effect of acetyl strophanthidin on the hearts of normal dogs.

Abstract

1. The ED50 of acetyl strophanthidin for producing ventricular arrhythmias in normal dogs was 54.5 mug/kg intravenously.2. Doses up to and including those which caused ventricular tachycardia did not produce either atrial arrhythmias or significant aberration of A-V conduction.3. Although the classic digitalis-induced rate and e.c.g. waveform changes may appear after administration of acetyl strophanthidin, their presence or absence have no value in predicting the subsequent development of ventricular arrhythmias.

• Authors: A H Hayes Jr, W P McShane, F R Sidell
• Journal: British journal of pharmacology (Br J Pharmacol) Vol. 38 Issue 3 Pg. 616-9 (May 1970) ISSN: 0007-1188 [Print] England
• PMID: 5441414 (Publication Type: Journal Article)

Chemical References

• Digitalis Glycosides

Topics

• Animals
• Arrhythmias, Cardiac (chemically induced, etiology)
• Digitalis Glycosides (pharmacology)
• Dogs
• Electrocardiography
• Heart (drug effects)
• Heart Atria (drug effects)
• Heart Conduction System (drug effects)
• Heart Rate (drug effects)
• Heart Ventricles (drug effects)
• Injections, Intravenous