Effects of thymus-independent (B) cells and the H-2 gene complex on antiviral function of immune thymus-derived (T) cells.

Abstract

Antiviral activity in vivo exerted by ectromelia virus-immune spleen cells transferred to ectromelia-infected recipients and cytotoxicity against virus-infected target cells in vitro were both properties of non-immunoglobulin (Ig)-bearing cells (which included T cells). Ig-bearing cells, including thymus-independent (B) cells and antibody-secreting cells, were much less active in vivo when injected alone and tended to block rather than amplify the effect triggered by T cells. Ig-bearing cells were also slightly active in vitro, possibly because some T cells have detectable Ig. Antiviral effects in cell transfer experiments were seen only when immune cell donors and infected recipients shared the same H-2 gene complex. These results are consistent with the hypothesis that the T cell response to ectromelia infection is directed against specific virus-induced change(s) in antigen(s), specified by gene(s) in the H-2 complex, which appear in virus-infected cells.

• Authors: R V Blanden, N A Bowern, T E Pang, I D Gardner, C R Parish
• Journal: The Australian journal of experimental biology and medical science (Aust J Exp Biol Med Sci) Vol. 53 Issue 3 Pg. 187-95 (Jun 1975) ISSN: 0004-945X [Print] Australia
• PMID: 53049 (Publication Type: Journal Article)

Chemical References

• Epitopes
• Histocompatibility Antigens
• Immunoglobulins

Topics

• Animals
• B-Lymphocytes (immunology, transplantation)
• Cytotoxicity Tests, Immunologic
• Ectromelia, Infectious (immunology)
• Epitopes
• Genes
• Histocompatibility
• Histocompatibility Antigens
• Immunity, Cellular
• Immunization, Passive
• Immunoglobulins
• Mice
• Mice, Inbred C57BL
• Mice, Inbred CBA
• Poxviridae Infections (immunology)
• Spleen (immunology)
• T-Lymphocytes (immunology, transplantation)
• Transplantation, Homologous
• Transplantation, Isogeneic