beta-Adrenoreceptor antagonists in essential tremor.

Abstract	Three different beta-adrenoreceptor antagonists--propranolol, sotalol, and atenolol--were compared in a double-blind study with placebo in nine patients with essential tremor. All three drugs produced an equal reduction in standing pulse rate but atenolol was less effective in reducing tremor than propranolol and sotalol. These results suggest that the reduction in tremor produced by beta-adrenoreceptor antagonists is mediated by an effect on peripheral beta 2-adrenoreceptors.
Authors	D Jefferson, P Jenner, C D Marsden
Journal	Journal of neurology, neurosurgery, and psychiatry (J Neurol Neurosurg Psychiatry) Vol. 42 Issue 10 Pg. 904-9 (Oct 1979) ISSN: 0022-3050 [Print] England
PMID	512665 (Publication Type: Clinical Trial, Comparative Study, Controlled Clinical Trial, Journal Article)
Chemical References	Placebos Propanolamines Atenolol Propranolol Sotalol
Topics	Adult Aged Atenolol (therapeutic use) Blood Pressure Double-Blind Method Female Humans Male Middle Aged Placebos Propanolamines (therapeutic use) Propranolol (therapeutic use) Pulse Sotalol (therapeutic use) Tremor (drug therapy)

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