Ergot-induced inhibition of pituitary tumor growth in rats.

Abstract	Daily injections of ergocornine or ergonovine, for 3 weeks, into rats carrying a prolactin- and growth hormone-secreting pituitary tumor (MtW15) induced significant regression or inhibition of tumor growth, whereas ergocryptine had no significant effect. Ergocornine caused a decrease in cells and a disappearance or pycnosis of nuclei in the tumor tissue, and a reduced concentration of prolactin in blood.
Authors	S K Quadri, K H Lu, J Meites
Journal	Science (New York, N.Y.) (Science) Vol. 176 Issue 4033 Pg. 417-8 (Apr 28 1972) ISSN: 0036-8075 [Print] United States
PMID	5026161 (Publication Type: Journal Article)
Chemical References	Ergolines Prolactin
Topics	Animals Ergolines (administration & dosage, pharmacology, therapeutic use) Female Injections, Intraperitoneal Neoplasm Transplantation Neoplasms, Experimental (drug therapy, metabolism, pathology) Pituitary Neoplasms (drug therapy, metabolism) Prolactin (analysis, metabolism) Radioimmunoassay Rats Rats, Inbred Strains Uterine Cervical Neoplasms (drug therapy)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.

Realize the full power of the drug-disease research graph!