Dry coating of intraocular lenses with bovine submaxillary mucin.

Abstract

Uncoated intraocular lenses caused extensive corneal endothelial cell damage after in vitro contact (mean, 30.9% cell loss), whereas lenses coated with bovine submaxillary mucin type 1 caused minimal cell loss (mean 4.3%). No observable in vivo toxicity in the eye occurred when 0.1 ml of 3, 6, or 9% solution was injected into the anterior chamber. Mucin-coated lenses can be sterilized by ethylene oxide with no measurable adsorbence into the coating. Scanning electron microscopy confirmed the results from vital staining.

• Authors: G A Peyman, K Zweig
• Journal: American journal of ophthalmology (Am J Ophthalmol) Vol. 87 Issue 4 Pg. 561-6 (Apr 1979) ISSN: 0002-9394 [Print] United States
• PMID: 443321 (Publication Type: Journal Article)

Chemical References

• Methacrylates
• Mucins

Topics

• Animals
• Corneal Diseases (prevention & control)
• Endothelium (drug effects)
• Eye (drug effects)
• Lenses, Intraocular (standards)
• Methacrylates
• Microscopy, Electron, Scanning
• Mucins (pharmacology, therapeutic use, toxicity)
• Rabbits
• Surface Properties