Tumor cell threshold required for suppression of macrophage inflammation.

Abstract

In DBA/2 mice bearing transplanted, syngeneic P815 mastocytoma, macrophage accumulation was impaired in the tumor when the cancer grew intraperitoneally. By varying the number of transplanted mastocytoma cells and quantitating the macrophage response to a standardized stimulus of proteose peptone, we determined that 4-16x10(6) mastocytoma cells were required to inhibit monocyte inflammation. That interference with monocyte inflammation required a threshold number of tumor cells was consistent with an increase in tumor-associated macrophages proportional to tumor growth during early cancer. It was also consonant with a greater number of macrophages in tumors initiated with small rather than large tumor inocula. Impairment of monocyte inflammation could be passively transferred with ascitic fluid.

• Authors: S J Normann
• Journal: Journal of the National Cancer Institute (J Natl Cancer Inst) Vol. 60 Issue 5 Pg. 1091-6 (May 1978) ISSN: 0027-8874 [Print] United States
• PMID: 417187 (Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)

Topics

• Animals
• Ascitic Fluid (immunology)
• Cell Count
• Inflammation (immunology, pathology)
• Macrophages (immunology, pathology)
• Mast-Cell Sarcoma (immunology)
• Mice
• Mice, Inbred DBA
• Monocytes (immunology)
• Peritoneal Neoplasms (immunology, pathology)
• Sarcoma, Experimental (immunology, pathology)