Failure of prolonged hypocapnia, hypothermia, or hypertension to favorably alter acute stroke in primates.

Abstract

The effects of induced hypocapnia, hypothermia, and hypertension were surveyed in a primate model of acute stroke during and following a 48-hour period of intensive care. The results were compared to a group of nine control animals previously studied. Hypocapnia (PaCO2=25 torr) was examined in five animals and did not appear to alter the expected mortality, degree of neurological deficit, or frequency of infarction. There was, however, a suggestion that the size of infarction may be reduced. Hypothermia (29 degrees C) in five animals had a detrimental effect in that no animals survived following the intensive care period and all had infarction with massive edema. We speculate that hypothermia caused a sufficient increase in blood viscosity as to compromise collateral flow, thereby accounting for this detrimental effect. Induced hypertension (to 20% above control levels) was abandoned after three animals because of severe systemic effects (cardiac failure and pulmonary edema) resulting in death during the period of intensive care.

• Authors: J D Michenfelder, J H Milde
• Journal: Stroke (Stroke) 1977 Jan-Feb Vol. 8 Issue 1 Pg. 87-91 ISSN: 0039-2499 [Print] United States
• PMID: 402043 (Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Angiotensin II
• Carbon Dioxide
• Phenylephrine
• Norepinephrine
• Epinephrine

Topics

• Acute Disease
• Angiotensin II (pharmacology)
• Animals
• Blood Pressure (drug effects)
• Blood Viscosity
• Carbon Dioxide (blood)
• Cerebrovascular Disorders (blood, complications, therapy)
• Disease Models, Animal
• Epinephrine (pharmacology)
• Female
• Haplorhini
• Hypertension (chemically induced)
• Hypothermia, Induced
• Male
• Norepinephrine (pharmacology)
• Phenylephrine (pharmacology)