Effect of tolazoline on renal function in newborn puppies.

Abstract

Tolazoline is used in pulmonary hypertension and hypoperfusion syndrome during the neonatal period. Some of the side effects of tolazoline are hypotension, bleeding disorders and renal dysfunction. The present study was designed to investigate the effect of hypoxia and tolazoline on renal function in newborn puppies. The data in normal animals administered tolazoline alone did not reveal any statistically significant changes in blood pressure or in renal function. In the hypoxia group changes in renal function were noticed in spite of normal blood pressure. When tolazoline was administered to the hypoxic animals, a marked decrease in blood pressure resulted. Indeed, changes in renal function were more profound in the hypoxic animals receiving tolazoline than in hypoxic animals not receiving tolazoline, even though some of the renal functional values did not reach statistical significance.

• Authors: E G John, R Bhat, F K Assadi, D Vidyasagar, L Fornell
• Journal: Developmental pharmacology and therapeutics (Dev Pharmacol Ther) Vol. 9 Issue 6 Pg. 402-11 ( 1986) ISSN: 0379-8305 [Print] Switzerland
• PMID: 3816493 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Tolazoline

Topics

• Animals
• Animals, Newborn (physiology)
• Dogs
• Hypoxia (physiopathology)
• Kidney (drug effects, physiology)
• Tolazoline (pharmacology)