Abstract |
Serum concentrations of penicillin were measured in 37 children with pneumonia. The mean serum concentration of penicillin was greater than 1.0 microgram/mL for 11 hours after intramuscular administration of 48,000 U/kg benethamine penicillin compound (nine children), for 26 hours after 48,000 U/kg aqueous procaine penicillin (10 children), and for 40 hours after 79,000 U/kg aqueous procaine penicillin (seven children). After intramuscular administration of 35,000 U/kg benzyl penicillin in 11 children, the serum concentration was 13.3 +/- 7.4 micrograms/mL (mean +/- SD) 30 minutes after the injection, and 4.9 +/- 3.2 micrograms/mL after 3 hours. Our findings lend support to the World Health Organization recommendation that children with mild pneumonia in developing countries be given daily intramuscular injections of 50,000 U/kg aqueous procaine penicillin.
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Authors | F Shann, V Linnemann, M Gratten |
Journal | The Journal of pediatrics
(J Pediatr)
Vol. 110
Issue 2
Pg. 299-302
(Feb 1987)
ISSN: 0022-3476 [Print] United States |
PMID | 3806306
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- benethamine penicillin
- Penicillin G
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Topics |
- Child
- Child, Preschool
- Humans
- Infant
- Penicillin G
(analogs & derivatives, blood, therapeutic use)
- Pneumonia
(blood, drug therapy)
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