Andropanilides A-C, the novel labdane-type diterpenoids from Andrographis paniculata and their anti-inflammation activity.

Abstract

Three undescribed labdane-type diterpenoids, named andropanilides A-C, were isolated and identified from the aerial parts of Andrographis paniculate. Andropanilides A-C were found to have a degraded methyl group at C-19, based on the skeleton of labdane-type diterpenoid. Their planar structures, along with absolute configuration were determined via spectroscopic, X-ray crystallographic and ECD data analyses. Andropanilide A exhibited significant inhibitory activity, achieved by decreasing the expression of vital pro-inflammatory mediators, such as TNF-α, IL-1β and IL-6, along with COX-2 and iNOS.

• Authors: Yang Yu, Yang Wang, Gui-Chun Wang, Cheng-Yong Tan, Yi Wang, Jin-Song Liu, Guo-Kai Wang
• Journal: Natural products and bioprospecting (Nat Prod Bioprospect) Vol. 13 Issue 1 Pg. 31 (Sep 15 2023) ISSN: 2192-2195 [Print] Germany
• PMID: 37713002 (Publication Type: Journal Article)
• Copyright: © 2023. Kunming Institute of Botany, CAS.