Activity of compound G2 isolated from alfalfa roots against medically important yeasts.

Abstract

An antimycotic agent was isolated from roots of alfalfa and further purified to yield a nonhemolytic, homogeneous compound (G2). This compound contained considerable activity against 10 medically important yeasts. MICs obtained by both agar and broth dilution methods ranged from 3 to 15 micrograms/ml. Compound G2 was fungicidal at a relatively low concentration for nine different species of yeasts tested (minimum fungicidal concentrations ranged between 6 and 24 micrograms/ml). The considerable stability of compound G2 and its strong inhibitory and fungicidal activity against a broad range of yeasts suggest that after further development it might be useful as an active agent in the treatment of mycotic infections.

• Authors: I Polacheck, U Zehavi, M Naim, M Levy, R Evron
• Journal: Antimicrobial agents and chemotherapy (Antimicrob Agents Chemother) Vol. 30 Issue 2 Pg. 290-4 (Aug 1986) ISSN: 0066-4804 [Print] United States
• PMID: 3767342 (Publication Type: Journal Article)

Chemical References

• Antifungal Agents
• Culture Media
• Plant Extracts
• Triterpenes
• medicagenic acid-3-O-glucopyranoside

Topics

• Animals
• Antifungal Agents (isolation & purification, pharmacology, toxicity)
• Culture Media
• Female
• Hydrogen-Ion Concentration
• Medicago sativa
• Mice
• Microbial Sensitivity Tests
• Plant Extracts (pharmacology)
• Triterpenes (pharmacology)
• Yeasts (drug effects)