Abstract |
Dapsone is frequently used as a bacteriostatic drug in the treatment of mastitis, endometritis and footrot (necrotic pododermatitis). The farmer usually obtains this drug by 'non-ethical' channels. A regular scheme of checking the milk for residues of sulphonamides will be introduced in 1986. The sensitivity of the test is approximately 25 ppb for Dapsone. This will result in lower milk price in the case of positive tests. In healthy animals, it is shown that intramuscular treatment with 35 grammes (+/- 70 mg/kg-1 body weight) of Dapsone results in residues of Dapsone and its metabolite monoacetyldapsone above this detection level for more than 6 1/2 days. Within 5 days after oral treatment with 48.75 grammes (+/- 100 mg/kg-1 body weight) and 2 1/2 days after single intramammary treatment with 0.8 grammes, the concentrations of residues detected dropped below 25 ppb. The other well-known metabolite diacetyldapsone was only present in detectable quantities in the first milkings after oral treatment.
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Authors | H W van Gend, M B Brinkman, H Mol, R Kommerij, F W van der Kreek |
Journal | Tijdschrift voor diergeneeskunde
(Tijdschr Diergeneeskd)
Vol. 111
Issue 19
Pg. 911-20
(Oct 01 1986)
ISSN: 0040-7453 [Print] Netherlands |
Vernacular Title | Het voorkomen van Dapson-residuen na éénmalige orale, intramusculaire en intramammaire toepassing bij gezonde melkrunderen. |
PMID | 3764871
(Publication Type: English Abstract, Journal Article)
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Chemical References |
- Sulfonamides
- Dapsone
- monoacetyldapsone
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Topics |
- Administration, Oral
- Animals
- Cattle
(metabolism)
- Dapsone
(administration & dosage, analogs & derivatives, analysis, metabolism)
- Female
- Injections, Intramuscular
- Mammary Glands, Animal
- Milk
(analysis)
- Sulfonamides
(analysis)
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