Effects of Cefixime on Immune Functions and Inflammatory Factors in Children with Urinary Tract Infection and Targeted Nursing Strategies.

Abstract

OBJECTIVE:

This study aims to explore the effects of cefixime on immune functions and inflammatory factors in children with urinary tract infection and to investigate its nursing strategies.

METHODS:

A total of 161 children with urinary tract infection who were diagnosed in our hospital from November 2019 to November 2021 were selected. All children were treated with cefixime and received targeted nursing strategies. The indices of immune functions and the levels of inflammatory factors were compared before and after the treatment. The satisfaction degree of children's family members, recurrence rate and incidence of adverse reactions were measured.

RESULTS:

The levels of CD3+, CD4+ and CD4+/CD8+ in children after the treatment were significantly higher but the CD8+ level was significantly lower than those before the treatment (p < 0.001). The levels of C-reactive protein, tumour necrosis factor-α and interleukin-6 after the treatment were lower than those before the treatment (p < 0.001). The average score of nursing satisfaction of children's family members was (84.53 ± 13.65) points, with the total satisfaction degree of 90.68% (146/161). Within 6 months after the treatment, only six children had urinary tract infection again and the recurrence rate was 3.73% (6/161). During the treatment, seven children had adverse reactions to the drug, with an incidence rate of 4.35% (7/161).

CONCLUSIONS:

Cefixime can improve the immune function of children with urinary tract infection and reduce the levels of inflammatory factors. The implementation of targeted nursing strategies can improve clinical satisfaction and reduce the recurrence rate of the disease and thus can be helpful to establish a comprehensive and efficient clinical program for children with urinary tract infection.

• Authors: Jing Han, Dan Luo, Xin Han
• Journal: Archivos espanoles de urologia (Arch Esp Urol) Vol. 76 Issue 5 Pg. 313-318 (Jul 2023) ISSN: 0004-0614 [Print] Spain
• PMID: 37545149 (Publication Type: Journal Article)
• Copyright: © 2023 The Author(s).

Chemical References

• Cefixime
• Cefotaxime

Topics

• Child
• Humans
• Cefixime (therapeutic use)
• Cefotaxime (adverse effects)
• Urinary Tract Infections (drug therapy)
• Administration, Oral
• Immunity