Abstract | OBJECTIVE: METHODS: This is a longitudinal, retrospective, and descriptive study. The medical records of 136 pediatric patients with Fanconi anemia who underwent hematopoietic stem cell transplantation between 2008 and 2018 at the Clinical Hospital of the Federal University of Paraná were reviewed. A specific protocol was created for data collection, which included age, sex, skin color, age at diagnosis of Fanconi anemia, transplantation data, family history of consanguinity, and pre- and post-transplant complications. In addition, the data included the presence of graft-versus-host disease of the skin and other organs, its classification, type of lesion, location, and also skin lesions not related to graft-versus-host disease. RESULTS: CONCLUSION: A high prevalence of cutaneous manifestations of the disease was observed, as well as cutaneous manifestations of graft-versus-host disease. The protocol developed gathers relevant and standardized information for the follow-up of patients with Fanconi anemia undergoing hematopoietic stem cell transplantation, ensuring greater reliability of the information, and its implementation will allow the prospective evaluation of patients.
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Authors | Leane Dhara Dalle Laste, Pâmela Schmidt, Gabriela Araujo Moreira, Janine Horsth Silva, Kerstin Taniguchi Abagge |
Journal | Revista paulista de pediatria : orgao oficial da Sociedade de Pediatria de Sao Paulo
(Rev Paul Pediatr)
Vol. 41
Pg. e2022059
( 2023)
ISSN: 1984-0462 [Electronic] Brazil |
PMID | 37466627
(Publication Type: Journal Article)
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Topics |
- Child
- Humans
- Fanconi Anemia
(therapy, diagnosis, pathology)
- Retrospective Studies
- Reproducibility of Results
- Graft vs Host Disease
(epidemiology, diagnosis, pathology)
- Erythema
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