Preparation of quaternized N-halamine modified graphene oxide based antibacterial hydrogel and wound healing of bacterial infection.

Abstract

In clinical practice, the wound on the surface of the skin is prone to bacterial infection, for which healing of infected wounds has always been a tremendous challenge for clinics and research institutions. We developed a multifunctional bactericidal, recyclable, and slow-release graphene oxide-based hydrogel for bacterial wound healing and real-time monitoring of bacterial infection in this study. At the same time, the material has a sensing function, which can be used in the connection between the injured skin and the continuous detection equipment. QNGH (quaternarized N-halamine-grafted GO hydrogel) is manufactured by hydrogen bonding between quaternized N-halamine-modified graphene oxide and polyvinyl alcohol (PVA). The results show that in the mouse model of full-thickness skin repair, the hydrogel can continuously release germicidal ions and recyclability, promoting wound healing and contraction. Further, the graphene oxide-based hydrogel has excellent strain sensing performance. It detects the bending and stretching movements of different parts of the human body quickly, stably, and sensitively to show an excellent real-time monitoring performance of human motion. The sensing function of the hydrogel further broadens its application field. Therefore, this hydrogel material is expected to be a candidate material for sensing devices at the wound.

• Authors: Danlin Bu, Xudong Liu, Yizhao Cao, Hengyu Feng, Ruiqiang Wang, Zice Xu, Linghan Xiao, Wei Zhu
• Journal: Colloids and surfaces. B, Biointerfaces (Colloids Surf B Biointerfaces) Vol. 229 Pg. 113451 (Sep 2023) ISSN: 1873-4367 [Electronic] Netherlands
• PMID: 37451225 (Publication Type: Journal Article)
• Copyright: Copyright © 2023 Elsevier B.V. All rights reserved.

Chemical References

• graphene oxide
• Hydrogels
• N-halamine
• Anti-Bacterial Agents

Topics

• Humans
• Animals
• Mice
• Hydrogels (pharmacology)
• Wound Healing
• Anti-Bacterial Agents (pharmacology)
• Bacterial Infections (drug therapy)