Remdesivir.

Abstract

Remdesivir, marketed under the brand name Veklury, is an antiviral drug with a broad spectrum of activity. There were various countries where the use of Remdesivir for the treatment of COVID-19 was authorized during the pandemic. Remdesivir was first designed to treat hepatitis C, but it was later tested for Ebola virus sickness and Marburg virus infections. Remdesivir is a prodrug designed to facilitate the intracellular transport of GS-441524 monophosphate and its subsequent biotransformation into GS-441524 triphosphate, a ribonucleotide analogue inhibitor of viral RNA polymerase. The objective of this chapter is to provide a comprehensive review of Remdesivir (GS-5734), including its nomenclature, physiochemical properties, preparation methods, identification procedures, numerous qualitative and quantitative analytical techniques, ADME profiles, and pharmacological effects. In addition, the chapter provides a variety of chromatographic and spectroscopic techniques for separating brimonidine from other drugs in combination formulations.

• Authors: Ahmed H Bakheit, Hany Darwish, Ibrahim A Darwish, Ahmed I Al-Ghusn
• Journal: Profiles of drug substances, excipients, and related methodology (Profiles Drug Subst Excip Relat Methodol) Vol. 48 Pg. 71-108 ( 2023) ISSN: 1871-5125 [Print] Netherlands
• PMID: 37061276 (Publication Type: Review, Journal Article)
• Copyright: Copyright © 2023 Elsevier Inc. All rights reserved.

Chemical References

• remdesivir
• Adenosine Monophosphate

Topics

• Humans
• COVID-19
• SARS-CoV-2
• COVID-19 Drug Treatment
• Adenosine Monophosphate (therapeutic use, pharmacology)