Osteogenic markers in peri-implant crevicular fluid in immediate and delayed-loaded dental implants: A randomized controlled trial.

Abstract

INTRODUCTION:

The study evaluates the levels of matrix metalloprotease-8 (MMP-8), and Cathepsin-K (CatK) in peri-implant crevicular fluid (PICF) among patients with immediate loaded (IL) and delayed-loaded (DL) implants at different time points to know the inflammation and osteogenic status.

METHODS:

The study population consisted of two groups (n = 25, each group) with a mean age of 28.7 ± 3.5 years, and PICF was collected. MMP-8 and CatK levels were quantified through ELISA.

RESULTS:

We observed the concentrations of inflammatory markers (MMP-8 and CatK) at three time points in the IL and DL groups. The mean concentration of MMP-8 in the IL group was 9468 ± 1230 pg/mL, 5547 ± 1088 pg/mL, and 7248 ± 1396 pg/mL at 2 weeks, 3 months, and 12 months, respectively; while in the DL group was 10 816 ± 779.7 pg/mL, 9531 ± 1245 pg/mL, and 9132 ± 1265 pg/mL at 2 weeks, 3 and 12 months, respectively. The mean concentration of Cat-K in the IL group was observed at 422.1 ± 36.46 pg/mL, 242.9 ± 25.87 pg/mL, and 469 ± 75.38 pg/mL at 2 weeks, 3, and 12 months, whereas in the DL group was 654.6 ± 152.9 pg/mL, 314.7 ± 28.29 pg/mL, and 539.8 ± 115.1 pg/mL at 2 weeks, 3 months and 12 months, respectively.

CONCLUSION:

In this study, the levels of CatK and MMP-8 levels decline at 12 months in both groups, and the IL group shows lower values compared to the DL group; however, no significant changes were observed after analyses were adjusted for multiple comparisons (p > 0.025). Therefore, there is not much difference observed in the inflammation process between immediate and delayed loading. (Clinical trial identifier: CTRI/2017/09/009668).

• Authors: Simran Rastogi, Komal Rani, Vaibhav Sharma, Prahalad Singh Bharti, Krishna Deo, Veena Jain, Aditi Nanda, Saroj Kumar, Dheeraj Kumar Koli
• Journal: Clinical implant dentistry and related research (Clin Implant Dent Relat Res) Vol. 25 Issue 3 Pg. 540-548 (Jun 2023) ISSN: 1708-8208 [Electronic] United States
• PMID: 36940923 (Publication Type: Randomized Controlled Trial, Journal Article)
• Copyright: © 2023 The Authors. Clinical Implant Dentistry and Related Research published by Wiley Periodicals LLC.

Chemical References

• Dental Implants
• Matrix Metalloproteinase 8

Topics

• Humans
• Dental Implants
• Matrix Metalloproteinase 8 (analysis)
• Inflammation
• Immediate Dental Implant Loading
• Osteogenesis
• Gingival Crevicular Fluid (chemistry)