Leveraging the ATP-P2X7 receptor signalling axis to alleviate traumatic CNS damage and related complications.

Abstract

The P2X7 receptor is an exceptional member of the P2X purinergic receptor family, with its activation requiring high concentrations of extracellular adenosine 5'-triphosphate (ATP) that are often associated with tissue damage and inflammation. In the central nervous system (CNS), it is highly expressed in glial cells, particularly in microglia. In this review, we discuss the role and mechanisms of the P2X7 receptor in mediating neuroinflammation and other pathogenic events in a variety of traumatic CNS damage conditions, which lead to loss of neurological and cognitive functions. We raise the perspective on the steady progress in developing CNS-penetrant P2X7 receptor-specific antagonists that leverage the ATP-P2X7 receptor signaling axis as a potential therapeutic strategy to alleviate traumatic CNS damage and related complications.

• Authors: Yaling Yin, Linyu Wei, Emily A Caseley, Osbaldo Lopez-Charcas, Yingjuan Wei, Dongliang Li, Steve P Muench, Sebastian Roger, Lu Wang, Lin-Hua Jiang
• Journal: Medicinal research reviews (Med Res Rev) Vol. 43 Issue 5 Pg. 1346-1373 (09 2023) ISSN: 1098-1128 [Electronic] United States
• PMID: 36924449 (Publication Type: Journal Article, Review, Research Support, Non-U.S. Gov't)
• Copyright: © 2023 The Authors. Medicinal Research Reviews published by Wiley Periodicals LLC.

Chemical References

• Receptors, Purinergic P2X7
• Purinergic P2X Receptor Antagonists
• Adenosine Triphosphate

Topics

• Humans
• Receptors, Purinergic P2X7
• Central Nervous System
• Microglia
• Purinergic P2X Receptor Antagonists (pharmacology, therapeutic use)
• Adenosine Triphosphate