Synthesis, Structural Characterization, and Cytotoxic Activity of New Benzo[d]imidazo[2,1-b]thiazole Derivatives Against MCF-7 Breast Cancer Cells.

Abstract

Breast cancer is an invasive disease with a high prevalence among females. Despite various treatments, studies are still ongoing to find an effective treatment for this disease. This study aimed to synthesize a new series of diaryl benzo[d]imidazo[2,1-b]thiazole compounds containing aminoethoxy side chain and in vitro investigate their cytotoxicity on a human breast cancer cell line (MCF-7). Twelve derivatives (6a-6l) were synthesized from this scaffold, the structures of which were spectroscopically confirmed. The cytotoxic effects of the derivatives on the MCF-7 cell line were also assessed using the MTT assay. All these compounds showed a good inhibitory effect on the MCF-7 cell line, compared to that of tamoxifen. Compounds (6i) and (6j) showed higher cytotoxicity with relevant inhibitory effects of 81% and 73%, respectively.

• Authors: Nahid Ahmadi, Soraya Shahhosseini, Farshad H Shirazi, Golrokh Farnam, Afshin Zarghi
• Journal: Iranian journal of pharmaceutical research : IJPR (Iran J Pharm Res) Vol. 21 Issue 1 Pg. e127041 (Dec 2022) ISSN: 1726-6890 [Electronic] Netherlands
• PMID: 36710987 (Publication Type: Journal Article)
• Copyright: Copyright © 2022, Author(s).