Endotoxin shock and tumour necrosis factor release in mannoheptulose-treated mice.

Abstract

Administration of mannoheptulose partially protected mice infected with Listeria monocytogenes against the lethal effect of a subsequent endotoxin challenge. The ability of these animals to produce tumour necrosis factor was however unaffected. Mannoheptulose was observed to reverse the hypoglycaemic effect of endotoxin, possibly through inhibition of insulin secretion. The therapeutic significance of these observations is discussed.

• Authors: Y M Choy, C P Cheng, L U Luey, S C Loh, K P Fung, C Y Lee
• Journal: Cancer letters (Cancer Lett) Vol. 37 Issue 1 Pg. 33-9 (Oct 1987) ISSN: 0304-3835 [Print] Ireland
• PMID: 3664450 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antitoxins
• Heptoses
• Lipopolysaccharides
• Tumor Necrosis Factor-alpha
• Mannoheptulose

Topics

• Animals
• Antitoxins (therapeutic use)
• Heptoses (therapeutic use)
• Hypoglycemia (prevention & control)
• Lipopolysaccharides (toxicity)
• Listeriosis (prevention & control)
• Male
• Mannoheptulose (therapeutic use)
• Mice
• Shock, Septic (prevention & control)
• Tumor Necrosis Factor-alpha (metabolism)