Abstract | PURPOSE: METHODS: PubMed, Google Scholar, EMBASE, and CINAHL databases were searched. The review protocol is registered in PROSPERO (CRD42021276796). Study selection, data extraction, and data analyses were performed in accordance with PRISMA guidelines. Random-effects model was used to quantify ADMA levels in the study groups. RESULTS: Eleven studies provided data on 1148 women. Mean plasma ADMA concentration was 0.04 μmol/L (95% confidence interval (CI) -0.06-0.15) higher in pregnant women with GDM than those without GDM, but no significant difference was observed. In contrast, our meta-analysis demonstrated a significant increase in postpartum mean ADMA concentration (Mean Difference (MD) 0.11 μmol/L; 95% CI 0.05-0.16) among women with previous GDM compared to women without previous GDM. CONCLUSION: Elevated ADMA levels in GDM may be a CVD risk factor, suggesting that ADMA may be a potential biomarker for early CVD risk prediction in women with GDM.
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Authors | Patricia Tiong, Logan Kosmider, Zohra S Lassi, Margaret A Arstall, Prabha H Andraweera |
Journal | Endocrine
(Endocrine)
Vol. 80
Issue 2
Pg. 283-291
(05 2023)
ISSN: 1559-0100 [Electronic] United States |
PMID | 36449126
(Publication Type: Meta-Analysis, Systematic Review, Journal Article)
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Copyright | © 2022. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature. |
Chemical References |
- N,N-dimethylarginine
- Arginine
|
Topics |
- Pregnancy
- Female
- Humans
- Diabetes, Gestational
- Postpartum Period
- Arginine
- Cardiovascular Diseases
(epidemiology, etiology)
|