Abstract | PURPOSE: METHODS AND MATERIALS: Patients (n = 142) were randomized to receive two cycles of paclitaxel/cisplatin/ 5-fluorouracil (TPF) IC followed by CCRT or CCRT alone. The primary end point was overall survival (OS). The secondary end points included the larynx-preservation rate, progression-free survival (PFS), distant metastasis-free survival (DMFS), and toxicities. RESULTS: Ultimately, 113 of the 142 patients were analyzed. With a median follow-up of 45.6 months (interquartile range 26.8-57.8 months), the 3-year OS was 53.1% in the IC + CCRT group compared with 54.8% in the CCRT group (hazard ratio, 1.004; 95% confidence interval, 0.573-1.761; P = 0.988). There were no statistically significant differences in PFS, DMFS, and the larynx-preservation rate between the two groups. The incidence of grade 3-4 hematological toxicity was much higher in the IC+ CCRT group than in the CCRT group (54.7% vs. 10%, P < 0.001). CONCLUSIONS: Adding induction TPF to CCRT did not improve survival and the larynx-preservation rate in locally advanced hypopharyngeal cancer, but caused a higher incidence of acute hematological toxicities. TRIAL REGISTRATION: ClinicalTrials.gov , number NCT03558035. Date of first registration, 15/06/2018.
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Authors | Xi Luo, Xiaodong Huang, Jingwei Luo, Jianping Xiao, Kai Wang, Yuan Qu, Xuesong Chen, Ye Zhang, Runye Wu, Jingbo Wang, Jianghu Zhang, Guozhen Xu, Li Gao, Shaoyan Liu, Xiaolei Wang, Xiaohui He, Dehong Luo, Junlin Yi |
Journal | BMC cancer
(BMC Cancer)
Vol. 22
Issue 1
Pg. 1235
(Nov 29 2022)
ISSN: 1471-2407 [Electronic] England |
PMID | 36447152
(Publication Type: Randomized Controlled Trial, Clinical Trial, Phase II, Journal Article)
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Copyright | © 2022. The Author(s). |
Topics |
- Humans
- Chemoradiotherapy
(adverse effects, methods)
- Hypopharyngeal Neoplasms
(therapy)
- Induction Chemotherapy
(adverse effects, methods)
- Larynx
- Progression-Free Survival
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