FMT: What's Next? A Narrative Review of Fecal Microbiota Transplantation in Clostridioides difficile Infection and Inflammatory Bowel Disease.

Abstract

Fecal microbiota transplantation (FMT) is an increasingly employed treatment option for Clostridioides difficile infection (CDI), with growing data supporting its safety and effectiveness in patients with concurrent inflammatory bowel disease (IBD). Given that alterations in the gut microbiome are associated with both ulcerative colitis (UC) and Crohn's disease (CD), the use of FMT for the treatment of IBD itself is another area of active investigation. In this narrative review, we highlight the evidence for use of FMT in the treatment of CDI in patients with IBD, as well as for IBD alone, and provide insight into the future of microbiome therapeutics.

• Authors: Sohum A Patwa, Christopher Ward, Colleen R Kelly
• Journal: Rhode Island medical journal (2013) (R I Med J (2013)) Vol. 105 Issue 9 Pg. 20-24 (Nov 01 2022) ISSN: 2327-2228 [Electronic] United States
• PMID: 36300959 (Publication Type: Review, Journal Article)

Topics

• Humans
• Fecal Microbiota Transplantation (adverse effects)
• Clostridioides difficile
• Treatment Outcome
• Clostridium Infections (therapy, complications)
• Inflammatory Bowel Diseases (therapy, complications)
• Chronic Disease